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:: Volume 25, Issue 3 (Spring 2021) ::
3 2021, 25(3): 174-180 Back to browse issues page
Effect of Intravitreal Bevacizumab with Vitamin D Ssupplementation on Diabetic Macular Edema in Vitamin D Deficient Patients
Abstract:   (879 Views)
Purpose: To determine the effect of intravitreal injection of bevacizumab (IVB), which is the standard treatment for diabetic macular edema, along with vitamin D supplementation, on diabetic macular edema in patients with vitamin D deficiency.
Methods: Generally, 83 eyes of 83 patients with diabetes mellitus (DM) type 2 and diabetic macular edema (DME) were studied. The patients were divided into 3 groups: normal vitamin D levels + IVB administration (Group 1, n=29), vitamin D insufficient/deficient + IVB administration (Group 2, n=26), and vitamin D insufficient/deficient + IVB administration+ oral vitamin D supplementation (Group 3, n=28). All groups received 3 monthly IVB injections and group 3 received oral vitamin D supplementation simultaneously. The patients were followed up 1, 3, and 6 months after the third baseline IVB with clinical examination, CDVA, and CMT measurements.
Results: The mean baseline CDVA (LogMAR) in groups 1, 2, and 3 was 0.68 ± 0.16, 0.72 ± 0.14, and 0.71 ± 0.1, respectively. In months 1, 3, and 6, after the basic triple IVB injection, visual acuity improved in all groups, but the increase in visual acuity in month 6 was statistically significant in the group treated with vitamin D supplement (group 3) and the group with normal vitamin D levels (group 1) compared to the vitamin D deficiency untreated group (group 2) (P<0.001). Mean CMT decreased in all groups following IVB injections (466.83 ± 57, 527.46 ± 42.3, and 500.61 ± 56.01 microns in groups 1, 2, and 3, respectively), but similar to visual acuity, only in month 6, these changes were significantly different in groups 1 and 3 compared to group 2 (P<0.001).
Conclusion: The correction of vitamin D deficiency in DME patients with type 2 diabetes and vitamin D deficiency, in addition to IVB injections, may play a role in improving CDVA and CMT.
Keywords: Diabetes Mellitus (DM), Diabetic Macular Edema (DME), Bevacizumab, Vitamin D
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Type of Study: Research | Subject: Ophthalmology
ePublished: 2021/05/31
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Effect of Intravitreal Bevacizumab with Vitamin D Ssupplementation on Diabetic Macular Edema in Vitamin D Deficient Patients. 3. 2021; 25 (3) :174-180
URL: http://binajournal.org/article-1-1083-en.html

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Volume 25, Issue 3 (Spring 2021) Back to browse issues page
مجله چشم‌پزشکی بینا Bina Journal of Ophthalmology
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