Cystoid macular edema (CME) is a painless disease with different etiologies, which manifests as multiple cyst like (cystoid) spaces in the macula. CME is a common cause of vision loss following cataract surgery. Some risk factors for post-cataract surgery CME include intraoperative complications specially incarceration of vitreous in the surgical wound, history of diabetes, uveitis and postoperative inflammation and infection. Clinical examination, fluorescein angiography and OCT are beneficial in the diagnosis of this disease. Since, it is a self-limiting disease, no standard therapy has been developed despite topical NSAIDs, periocular and intravitreal steroid injection and oral carbonic anhydrase inhibitors are used in chronic cases.