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:: Volume 15, Issue 3 (4-2010) ::
3 2010, 15(3): 167-176 Back to browse issues page
Keratolimbal Allograft in Total Limbal Stem Cell Deficiency
AR Baradaran-Rafii MD , A Abdolahi MD, MH Jabarpoor Bonyadi MD, A Mirdehghan MD, M Zare Joshaghani MD, B Einollahi MD, MA Javadi MD, F Karimian MD, MR Jafarinasab MD
Shahid Beheshti University of Medical Sciences
Abstract:   (2477 Views)

 

Purpose: To investigate the outcomes of keratolimbal allograft (KLAL) for treatment of total limbal stem cell deficiency (LSCD).

Method: Patients with total LSCD and adequate tear production were included. A total of 27 KLAL procedures were performed in 21 eyes of 20 patients with LSCD. Immunosuppression was achived using mycophenolate and cyclosporine. Main outcome measure was improvement in vision; in addition, KLAL survival and post operative complications were studied.

Results: Mean follow up period was 22.14±11.83 months (range 6-39). Mean visual acuity improved from 2.53± 0.21 to 1.49±0.77 LogMAR (P<0.0001). Six KLALs never re-epithelialized and were considered as primary failures. Mean KLAL survival was 14.23±1.5 months. Graft survival rate was 61.9% at 1 year and 31% at 20 months. Complications included corneal ulcers in 6, glaucoma in 2 and scleral thining in 1 case.

Conclusion: Keratolimbal allograft surgery is successful in the short term for visual rehabilitation of patients with total limbal stem cell deficiency.

Keywords: Keratolimbal Allograft, KLAL, Limbal Stem Cell Deficiency, Immunosupression
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Type of Study: Research | Subject: Ophthalmology
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Baradaran-Rafii A, Abdolahi A, Jabarpoor Bonyadi M, Mirdehghan A, Zare Joshaghani M, Einollahi B, et al . Keratolimbal Allograft in Total Limbal Stem Cell Deficiency. 3. 2010; 15 (3) :167-176
URL: http://binajournal.org/article-1-331-en.html


Volume 15, Issue 3 (4-2010) Back to browse issues page
مجله چشم‌پزشکی بینا Bina Journal of Ophthalmology
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