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:: Volume 22, Number 2 (1-2017) ::
3 2017, 22(2): 104-109 Back to browse issues page
Association between Polymorphisms of Rs4151667(L9H) CFB Gene and Age-Related Macular Degeneration in a Population in the North West of Iran
N Roshanipour Roshanipour, M Jabbarpour Bonyadi , MH Jabbarpour Bonyadi, A Javadzadeh
Abstract:   (127 Views)
Purpose: To investigate­ the possible association of polymorphisms of rs4151667(L9H) B gene with age-related macular degeneration (AMD) in a population from the North West of Iran.
Methods: In this study, 56 patients with AMD and 144 age-, sex-, and ethnic-matched controls were recruited. Both patients and controls were selected from the North West of Iran. The association of polymorphisms of rs4151667(L9H) CFB gene with AMD was investigated using polymerase chain reaction (PCR) and digested fragment length polymorphism technique (RFLP).
Results:­  A significant association was found between the polymorphism of rs4151667(L9H) CFB gene and AMD disease. (P=0.01 for TT genotype and P=0.02 for AT genotype)
­Conclusion: The TT genotype increases the likelihood of AMD by 2.6 times as compared to genotypes other than TT, whereas the AT genotype has a protective effect against the disease.
Keywords: AMD, CFB gene, PCR-RFLP, Polymorphism
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Type of Study: Research | Subject: Ophthalmology
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Roshanipour Roshanipour N, Jabbarpour Bonyadi M, Jabbarpour Bonyadi M, Javadzadeh A. Association between Polymorphisms of Rs4151667(L9H) CFB Gene and Age-Related Macular Degeneration in a Population in the North West of Iran. 3. 2017; 22 (2) :104-109
URL: http://binajournal.org/article-1-862-en.html
Volume 22, Number 2 (1-2017) Back to browse issues page
مجله چشم‌پزشکی بینا Bina Journal of Ophthalmology
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