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:: Volume 23, Issue 1 (10-2017) ::
3 2017, 23(1): 13-21 Back to browse issues page
Short-term Outcomes of Trabeculectomy with Intratenon ‎Injection of MMC versus Conventional Method
MM. Hatami , M. Pakravan ‎, Yazdani ‎, Douzandeh ‎, Yaseri
Ocular Tissue Engineering Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (1239 Views)
Purpose: To compare the short-term outcomes of intratenon injection of mitomycin C (MMC) with the conventional application of MMC soaked sponges in trabeculectomy.
Methods: In this randomized clinical trial, 80 open angle glaucoma cases were randomly divided into 2 groups; group 1 received an intratenon injection of 0.1 mL of 0.01% MMC, while group 2 received 0.02% MMC soaked sponges. Intraocular pressure (IOP), endothelial cell count (ECC) changes and bleb morphology, according to the Indiana bleb appearance grading scale (IBAGS) ,were evaluated at 1, 3, and 6 months after surgery and compared between 2 groups. Complete and qualified success was defined as IOP within 6-15 mmHg without and with medications at month 6, respectively.
Results: The mean preoperative IOP was 21.8±5.1 in group 1, which reduced to 10.3±3.7 mmHg at the final visit (P<0.001). Corresponding values for group 2 were 21.8±5 and 10.8±3.5 mmHg, respectively (P<0.001). Complete success was 82.5% and 87.5% in groups 1 and 2, respectively (P=0.526). The blebs tended to be more diffuse, shallower, and less vascularized in group 1, at month 6 (P=0.45, 0.001, and <0.001, respectively). Endothelial cell counts did not change significantly at the final visit (P=0.813).
Conclusion: Intratenon injection of MMC is a safe and effective method and produces more favorable bleb morphology after trabeculectomy.
Keywords: Bleb morphology, Intratenon Injection, Mitomycin C, Trabeculectomy‎
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Type of Study: Research | Subject: Ophthalmology
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Hatami M, Pakravan ‎ M, Yazdani ‎, Douzandeh ‎, Yaseri. Short-term Outcomes of Trabeculectomy with Intratenon ‎Injection of MMC versus Conventional Method. 3. 2017; 23 (1) :13-21
URL: http://binajournal.org/article-1-917-en.html

Volume 23, Issue 1 (10-2017) Back to browse issues page
مجله چشم‌پزشکی بینا Bina Journal of Ophthalmology
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