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:: Volume 23, Issue 1 (10-2017) ::
3 2017, 23(1): 41-49 Back to browse issues page
Corneal Graft after Cultivated Oral Mucosal Epithelial ‎Transplantation for Visual Rehabilitation in Chemical Burn
AR. Baradaran-Rafii , S. Delfazayebaher , N. Aghdami , G. Baradaran-Rafii , D. Roshandel , E. Taghiabadi , S. Bamdad , A. Masoudi ‎
Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (185 Views)
Purpose: To evaluate result of Corneal graft (PKP) after cultivated oral mucosal epithelial transplantation (COMET) in patients with chemical burn.
Methods: In this prospective interventional nonrandomized case series, optical PKP was performed after successful COMET for visual rehabilitation in patients with severe stromal opacity. Main outcome measures were clarity of the corneal graft, visual acuity improvement, and corneal graft survival.
Results: Fourteen eyes of 14 patients with successful COMET were included. Overall, PKP was performed 7.6±1.3 months (6-9 months) after COMET. The mean follow-up period was 28.2±8 months (14-40 months, median 30 months). The time for complete epithelial healing was 7 days in all eyes. There was no epithelial defect in 13 eyes at the final examination. The corneal surface had been covered by a transparent epithelium without significant neovascularization. Bacterial keratitis developed in 1 eye due to persistent epithelial defect, which was healed with vascularization. Best-corrected visual acuity increased from 2.67±0.08 LogMAR preoperatively to 0.64±0.27 LogMAR after PKP (P<.001). Four patients had Endothelial rejection that successfully managed by systemic and topical steroids. Overall and rejection-free graft survival rates were 92.9 and 69.2%, respectively.
Conclusion: PKP is a good choice for visual rehabilitation in chemical burn with bilateral total LSCD and severe stromal opacity that underwent successful COMET.
Keywords: Chemical Burn, Cultivated Oral Mucosal Epithelial Transplantation, Limbal Stem Cell Deficiency, Corneal ‎Graft
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Type of Study: Research | Subject: Ophthalmology
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Baradaran-Rafii A, Delfazayebaher S, Aghdami N, Baradaran-Rafii G, Roshandel D, Taghiabadi E, et al . Corneal Graft after Cultivated Oral Mucosal Epithelial ‎Transplantation for Visual Rehabilitation in Chemical Burn. 3. 2017; 23 (1) :41-49
URL: http://binajournal.org/article-1-919-en.html


Volume 23, Issue 1 (10-2017) Back to browse issues page
مجله چشم‌پزشکی بینا Bina Journal of Ophthalmology
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