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:: Volume 19, Issue 1 (10-2013) ::
3 2013, 19(1): 72-76 Back to browse issues page
Anterior Segment Eye Deposits following Long-term Chlorpromazine Therapy
H Norouzi MD, H Mohammad Rabei MD , A Lashgari MD
Shahid Beheshti University of Medical Sciences
Abstract:   (3836 Views)

Purpose: To report a case of anterior segment eye deposits in a patient on long-term chlorpromazine therapy.

Case Report: A 34 years old man had been on chlorpromazine therapy for 5 years with a total dose of 1,100 gram. Since one year ago, He presented with gradual onset of decreased visual acuity in both eyes. Slit-lamp examination revealed multiple fine yellow-brown deposits on the corneal endothelium, especially in the interpalpebral portion, and stellate opacity on the anterior crystalline lens capsule in both eyes. In vivo confocal microscopy identified multiple hyperreflective irregular dot-shaped deposits, varying in size, with a peak density at the level of pre-Descemet’s membrane.

Conclusions: Long-term chlorpromazine therapy induced irreversible deposits in the corneal endothelium and crystalline lens, which can lead to visual loss. Therefore, periodic ophthalmologic examinations are useful in patients who take chlorpromazine for long-term duration.

Keywords: Chlorpromazine, Corneal Deposits, Confocal Microscopy, Cataract
Full-Text [PDF 214 kb]   (753 Downloads)    
Type of Study: Research | Subject: Ophthalmology
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Norouzi H, Mohammad Rabei H, Lashgari A. Anterior Segment Eye Deposits following Long-term Chlorpromazine Therapy. 3. 2013; 19 (1) :72-76
URL: http://binajournal.org/article-1-146-en.html

Volume 19, Issue 1 (10-2013) Back to browse issues page
مجله چشم‌پزشکی بینا Bina Journal of Ophthalmology
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